An open-label trial of divalproex sodium extended release for pediatric bipolar spectrum disorder in children age 6 - 12 years

An open-label trial of divalproex sodium extended release for pediatric bipolar spectrum disorder in children age 6 - 12 years

Objective: To estimate the rate of response to divalproex sodium extended release in pediatric bipolar spectrum disorder in young children age 6 12. Methods: This was an 8-week, open-label treatment of youth with DSM-IV bipolar disorder with divalproex sodium extended release (ER) monotherapy. Severity of mania was assessed weekly with the Young Mania Rating Scale (YMRS). Results: The sample wa...

naltrexone in obsessive-compulsive disorder: an open- label trial

objective: in spite of introduction of novel drugs, obsessive-compulsive disorder (ocd) has still found no suitable treatment. on the other hand, high rates of co-morbidity of ocd with bipolar spectrum disorders are increasingly recognized. mood switching and development of rapid cycling with antidepressants are significant problems in these patients. from this viewpoint, introducing a non-anti...

Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial.

BACKGROUND To test the effectiveness and safety of omega-3 fatty acids (Omegabrite(R) brand) in the treatment of pediatric bipolar disorder (BPD). METHOD Subjects (N=20) were outpatients of both sexes, 6 to 17 years of age, with a DSM-IV diagnosis of BPD and Young Mania Rating Scale (YMRS) score of >15 treated over an 8-week period in open-label trial with omega-3 fatty acids 1290 mg-4300 mg ...

Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes

Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes Mani N. Pavuluri*, Alessandra M. Passarotti, Lisa H. Lu, Julie A. Carbray, John A. Sweeney a Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL USA; b Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at ...

Efficacy and Safety of Aripiprazole for Treatment of Irritability in Children with Autistic Disorder: An Open-Label Study